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Genetic susceptibility of cardiometabolic outcomes in schizophrenia spectrum disorders.

Schizophrenia research - 1 Jun 2026

Zhao Chenxu, Lin Bochao, Naderi Elnaz, Moazzen Sara, Habtewold Tesfa Dejenie, Bruggeman Richard, van Amelsvoort Therese, Cahn Wiepke, de Haan Lieuwe, van der Pluijm Marieke, Simons Claudia J P, van Os Jim, Veling Wim, Alizadeh Behrooz Z

Abstract excerpt

Patients with schizophrenia spectrum disorders (SSDs) have a higher risk for post-diagnostic cardiometabolic comorbidities. While antipsychotic use partly explains this, the contribution of genetic susceptibility remains unclear. We investigated the relationships between cardiometabolic-related polygenic risk scores (PRSes) with cardiometabolic outcomes using data from 671 patients with SSDs in the Dutch Genetic...

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PMID: 41861696
DOI: 10.1016/j.schres.2026.03.009

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