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Article

Genomic biomarkers of liver toxicity risk from UK Biobank data.

The pharmacogenomics journal - 28 Oct 2025

Shteto Anna, Boulahfa Jawad, Etcheto Adrien, Zhong Yann, Kindermans Martin, Parmentier Frederic, Goodsaid Federico

Abstract excerpt

Predictive safety risk biomarkers for drug-induced liver injury (DILI) are critically needed to enhance patient risk stratification and minimize adverse outcomes. This study aims to identify genomic markers associated with increased mortality in toxic liver disease, using the KEM® (Knowledge Extraction and Management) explainable Artificial Intelligence platform. From 225 participants diagnosed with toxic liver...

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Identifiers

PMID: 41152271
DOI: 10.1038/s41397-025-00389-8

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PRKAG2

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