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Article

Machine Learning to Identify Interaction of Single-Nucleotide Polymorphisms as a Risk Factor for Chronic Drug-Induced Liver Injury.

International journal of environmental research and public health - 10 Oct 2021

Moore Roland, Ashby Kristin, Liao Tsung-Jen, Chen Minjun

Abstract excerpt

Drug-induced liver injury (DILI) is a major cause of drug development failure and drug withdrawal from the market after approval. The identification of human risk factors associated with susceptibility to DILI is of paramount importance. Increasing evidence suggests that genetic variants may lead to inter-individual differences in drug response; however, individual single-nucleotide polymorphisms (SNPs) usually...

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PMID: 34682349
DOI: 10.3390/ijerph182010603
PMCID: PMC8535865

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