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Article

Predictive genetic testing for drug-induced liver injury: considerations of clinical utility.

Clinical pharmacology and therapeutics - 1 Sept 2012

Alfirevic A, Pirmohamed M

Abstract excerpt

Genetic predisposition to drug-induced liver injury may be due to variation in both pharmacokinetic and pharmacodynamic pathways. Recent genome-wide association studies have identified, in the human leukocyte antigen (HLA) alleles, strong genetic factors that predispose to liver injury on exposure to any of several drugs. Although the genetic associations have provided mechanistic insights, none has been...

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Identifiers

PMID: 22850601
DOI: 10.1038/clpt.2012.107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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