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Article

Genomic landscape of endometrial polyps.

Genome medicine - 24 Oct 2025

Reinikka Siiri, Mehine Miika, von Nandelstadh Pernilla, Ahvenainen Terhi, Khamaiseh Sara, Nousiainen Susanna, Jokinen Vilja, Pasanen Annukka, Bützow Ralf, Sarvilinna Nanna, Pitkänen Esa, Vahteristo Pia

Abstract excerpt

BACKGROUND: Endometrial polyps are common, localized overgrowths of endometrial glands and stroma that protrude into the uterine cavity. These tumor-like lesions can cause symptoms like abnormal uterine bleeding and infertility, and they may undergo malignant transformation. The etiology of endometrial polyps remains largely unknown. METHODS: Here, we conducted whole-genome sequencing and global gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41137179
DOI: 10.1186/s13073-025-01556-z
PMCID: PMC12553238

Genes

HMGA1
HMGA2
UBE2A
KRAS
LRMDA
PIK3CA
PLAG1
PTEN
RAD51B
TRAF3IP2

Provenance

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