Article

Rapid protein evolution by few-shot learning with a protein language model

2024-07-18

Abstract excerpt

Directed evolution of proteins is critical for applications in basic biological research, therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor intensive, cannot efficiently optimize over multiple protein properties, and are often trapped by local maxima. In silico- directed evolution methods incorporating protein language models (PLMs) have the potential to accelerate this...

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Literature Corpus work: a9d486c4-b340-536f-9b8e-2a3444bfd666
DOI: 10.1101/2024.07.17.604015

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