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Article

Higher Circulating Testosterone Linked to Higher CAD Risk in Men: Mendelian Randomization and Survival Analyses.

The Journal of clinical endocrinology and metabolism - 17 Mar 2026

Morbey Emily J, Day Felix R, Butterworth Adam S, Wareham Nicholas J, Perry John R B, Ong Ken K

Abstract excerpt

CONTEXT: Testosterone supplementation is increasingly widespread and has well-established beneficial effects on sexual function and metabolic health. However, there remains uncertainty regarding associated cardiovascular risks. OBJECTIVE: Human genetics studies demonstrated that Mendelian randomization approaches recapitulate the beneficial effects of testosterone therapy; here we apply this to cardiovascular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41131989
DOI: 10.1210/clinem/dgaf582
PMCID: PMC7618652

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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