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Article

Effects of lifelong testosterone exposure on health and disease using Mendelian randomization.

eLife - 16 Oct 2020

Mohammadi-Shemirani Pedrum, Chong Michael, Pigeyre Marie, Morton Robert W, Gerstein Hertzel C, Paré Guillaume

Abstract excerpt

Testosterone products are prescribed to males for a variety of possible health benefits, but causal effects are unclear. Evidence from randomized trials are difficult to obtain, particularly regarding effects on long-term or rare outcomes. Mendelian randomization analyses were performed to infer phenome-wide effects of free testosterone on 461 outcomes in 161,268 males from the UK Biobank study. Lifelong...

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Identifiers

PMID: 33063668
DOI: 10.7554/eLife.58914
PMCID: PMC7591257

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