Article

Loss of phosphorylation sites required for β-arrestin recruitment in the calcium-sensing receptor cytoplasmic region may contribute to hypocalcemia

2026-04-23

Abstract excerpt

The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) with an important role in calcium homeostasis, activating mutations of which cause hypocalcemia. Despite the receptors clinical importance and evidence suggesting β-arrestin-1/2 can modulate CaSR signaling, the residues within CaSR required for β-arrestin recruitment and the role of β-arrestin in desensitization, trafficking and sig...

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Literature Corpus work: fc364733-f427-5911-9c71-c58e9c926d5f
DOI: 10.64898/2026.04.21.719673

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