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Article

Bidirectional Mendelian Randomization Analysis Reveals Protective Effects of Bioavailable Testosterone Against Hypertensive Disorders of Pregnancy.

American journal of hypertension - 1 Apr 2026

Zhang Hua, Chen Qing, Ding Pan, Chang Yinan, Cheng Dong, Li Mu

Abstract excerpt

BACKGROUND: Hypertensive disorders of pregnancy (HDP) substantially increase maternal and fetal morbidity and mortality. Although reduced circulating bioavailable testosterone (BT) has been observed in women with HDP, the causal relationship and underlying mechanisms remain unresolved. Based on previous clinical and experimental evidence, we hypothesized a potential causal relationship between BT levels and HDP,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 41117793
DOI: 10.1093/ajh/hpaf208

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NFKBIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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