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Identification of Circulating Proteins Associated With Blood Pressure Using Mendelian Randomization.

Circulation. Genomic and precision medicine - 1 Feb 2020

Thériault Sébastien, Sjaarda Jennifer, Chong Michael, Hess Sibylle, Gerstein Hertzel, Paré Guillaume

Abstract excerpt

BACKGROUND: Hypertension is a common modifiable risk factor for cardiovascular disease and mortality. Pathophysiological mechanisms leading to hypertension remain incompletely understood. Mendelian randomization (MR) allows the evaluation of the causal role of markers by minimizing the risk of biases such as reverse causation and confounding. We aimed to identify novel circulating proteins associated with blood...

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Blood Pressure
Canada
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Risk Assessment

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PMID: 31928076
DOI: 10.1161/CIRCGEN.119.002605

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