Article
Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1.
Leukemia & lymphoma - 1 Jun 2020
Nguyen Lynh, Zhang Xiaohui, Roberts Evans, Yun Seongseok, McGraw Kathy, Abraham Ivo, Song Jinming, Braswell Diana, Qin Dahui, Sallman David A, Lancet Jeffrey E, List Alan F, Moscinski Lynn C, Padron Eric, Zhang Ling
Abstract excerpt
Studies comparing the prognostic role of RUNX1 mutations (RUNX1mut) in acute myeloid leukemia (AML) and acute myeloid leukemia-with myelodysplasia-related changes (AML-MRC) are limited. Our study examines the genetic profile of 118 RUNX1mut AML patients including 57 AML with RUNX1mut and 61 AML-MRC with RUNX1mut and 100 AML, NOS patients with wild type RUNX1 (RUNX1wt). Results revealed that AML-MRC patients with...
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