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Article

Associations of intrinsic capacity deficit proxy score and genetic susceptibility with incident chronic kidney disease and life expectancy.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 Oct 2025

Zheng Gang, Ou Fengrong, Chen Shuxian, Ji Chao, Chang Qing, Wang Difei, Yang Honghao, Ma Zheng, Xia Yang, Zhao Yuhong

Abstract excerpt

BACKGROUND: Intrinsic capacity (IC), reflecting an individual's physical and mental capacities, is a core concept proposed by the World Health Organization (WHO) to promote healthy aging. This study aimed at examining the association between IC and chronic kidney disease (CKD) incidence and outcomes. METHODS: We analyzed 389 805 UK Biobank participants without baseline CKD. Functional decline was quantified using...

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PMID: 41105198
DOI: 10.1093/gerona/glaf187

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