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Article

Genetically predicted frailty index and risk of chronic kidney disease.

Scientific reports - 19 Sept 2024

Chen Hui Juan, Qiu Jie, Guo Yihao, Chen Feng

Abstract excerpt

Previous findings have reported the association between frailty and chronic kidney disease. However, the causality remains ambiguous. This study aimed to determine whether frailty index is causally associated with chronic kidney disease. We obtained the frailty genome-wide association study (GWAS) data and chronic kidney disease GWAS data from the FinnGen R5 (total n = 216,743; case = 3902, control = 212,841) as...

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Frailty
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Renal Insufficiency, Chronic

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PMID: 39300167
DOI: 10.1038/s41598-024-71881-7
PMCID: PMC11412968

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