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Article

Convergence of genetic variants in MCR-1 and O-antigen conferring polymyxin resistance and fitness cost.

Journal of global antimicrobial resistance - 1 Dec 2025

Lu Jinfeng, Zhou Aiping, Wang Dongjiang, Wan Shuang, Yang Yuting, Lv Na, Li Jun, Wu Guoping

Abstract excerpt

OBJECTIVE: The emergence of multidrug-resistant bacteria alongside the extensive spread of opportunistic pathogens with a diversity of serotypes threatens public health. Fitness cost and morphological variation are hypothesised to result from O-antigen diversity and lipid A modification, whereas these reconfigurations within lipopolysaccharides (LPS) confer polymyxin resistance. METHODS: In this study, a...

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PMID: 41101560
DOI: 10.1016/j.jgar.2025.10.005

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