The mcr-1 plasmid carrying ecaR promotes virulence-associated phenotypes in Escherichia coli beyond colistin resistance: Implications for poultry-associated food safety.

Abstract excerpt

Plasmid-borne mcr-1 has been disseminated globally through the food chain, raising major concerns in food safety. We previously reported that mcr-1 plasmids carrying the transcriptional regulator gene ecaR activate surface polysaccharide production in Escherichia coli, converting a rough phenotype to smooth and enhancing virulence in a murine model. Here, we examined host-side consequences of this surface...

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