Article
Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein.
Rheumatology (Oxford, England) - 1 Oct 2013
Terao Chikashi, Yoshifuji Hajime, Ohmura Koichiro, Murakami Kosaku, Kawabata Daisuke, Yurugi Kimiko, Tazaki Junichi, Kinoshita Hideyuki, Kimura Akinori, Akizuki Masashi, Kawaguchi Yasushi, Yamanaka Hisashi, Miura Yasuo, Maekawa Taira, Saji Hiroo, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
OBJECTIVE: Takayasu arteritis (TAK) is a rare autoimmune arteritis that affects large arteries. Although the association between TAK and HLA-B 52:01 is established, the other susceptibility HLA-B alleles are not fully known. We performed genetic association studies to determine independent HLA-B susceptibility alleles other than HLA-B 52:01 and to identify important amino acids of HLA-B protein in TAK...
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