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Article

Loss of expression of STK11 / LKB1 in intratubular large cell hyalinizing Sertoli cell neoplasm

16 Jul 2025

Abstract excerpt

AIMS: Intratubular large cell hyalinizing Sertoli cell neoplasia (ILCHSCN) is a rare testicular sex cord stromal tumour that occurs in paediatric patients in the context of Peutz-Jeghers syndrome, a condition caused by germline STK11 alterations. The diagnosis of ILCHSCN and its distinction from large cell calcifying Sertoli cell tumour (LCCSCT), a neoplasm associated with loss of function PRKAR1A mutations, can...

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PMID: 41090222
DOI: 10.1111/his.15513

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