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Overexpression of Aromatase Associated With Loss of Heterozygosity of the<i>STK11</i>Gene Accounts for Prepubertal Gynecomastia in Boys with Peutz-Jeghers Syndrome

14 Sept 2013

Abstract excerpt

CONTEXT: Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. PJS males often have estrogen excess manifesting as gynecomastia and advanced bone age. We and others have previously described an increase in testicular aromatase expression in PJS patients. However, the underlying mechanism has not yet been explored. OBJECTIVE:...

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PMID: 24037887
DOI: 10.1210/jc.2013-2291

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Overexpression of Aromatase Associated With Loss of Heterozygosity of the<i>STK11</i>Gene Accounts for Prepubertal Gynecomastia in Boys with Peutz-Jeghers SyndromePMID 24037887Read ↗

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