Article
A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated With Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor): A Report of 22 Cases.
The American journal of surgical pathology - 1 Aug 2021
Bennett Jennifer A, Young Robert H, Howitt Brooke E, Croce Sabrina, Wanjari Pankhuri, Zhen Chaojie, Da Cruz Paula Arnaud, Meserve Emily, Schoolmeester J Kenneth, Westbom-Fremer Sofia, Benzi Eduardo, Patil Ninad M, Kooreman Loes, El-Bahrawy Mona, Zannoni Gian Franco, Krausz Thomas, McCluggage W Glenn, Weigelt Britta, Ritterhouse Lauren L, Oliva Esther
Abstract excerpt
We describe 22 examples of a novel, usually paratubal, adnexal tumor associated with Peutz-Jeghers syndrome in nearly 50% of cases that harbored STK11 alterations in all tested (n=21). The patients ranged from 17 to 66 years (median=39 y) and the tumors from 4.5 to 25.5 cm (median=11 cm). Most (n=18) were paratubal, with metastases noted in 11/22 (50%) and recurrences in 12/15 (80%). Morphologically, they were...
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