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Large cell calcifying Sertoli cell tumour: molecular and immunohistochemical assessment of a series comprising non-metastasising and metastasising neoplasms.

Histopathology - 1 Jun 2023

Yu Sanhong, Sholl Lynette M, Siegmund Stephanie, Ulbright Thomas M, Collins Katrina, Colecchia Maurizio, Del Pilar Gonzalez-Peramato Maria, Michalová Květoslava, Gordetsky Jennifer B, Cornejo Kristine M, Kao Chia-Sui, Wobker Sara E, Vargas Sara O, Maclean Fiona, Idrees Muhammad T, Anderson William J, Fletcher Christopher D M, Acosta Andres M

Abstract excerpt

Large cell calcifying Sertoli cell tumour (LCCSCT) is a type of testicular sex cord-stromal tumour that may occur sporadically or in the context of Carney complex and other genetic syndromes. A subset is clinically malignant, and the molecular mechanisms that drive such aggressive behaviour remain unknown. METHODS AND RESULTS: We analysed 21 samples from 20 patients with LCCSCT (12 non-metastasising and eight...

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PMID: 36929593
DOI: 10.1111/his.14895

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