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Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges

14 Feb 2023

Abstract excerpt

Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular processes causally associated with the development of diabetes can provide important evidence bases for disease prevention and spur novel therapeutic strategies. Mendelian randomisation (MR), an epidemiological approach that uses genetic instruments to infer causal associations between an...

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PMID: 36786839
DOI: 10.1007/s00125-023-05879-7

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