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Article

High functional allelic diversity and copy number in both MHC classes in the common buzzard.

BMC ecology and evolution - 24 Jun 2023

Winternitz Jamie, Chakarov Nayden, Rinaud Tony, Ottensmann Meinolf, Krüger Oliver

Abstract excerpt

BACKGROUND: The major histocompatibility complex (MHC), which encodes molecules that recognize various pathogens and parasites and initiates the adaptive immune response in vertebrates, is renowned for its exceptional polymorphism and is a model of adaptive gene evolution. In birds, the number of MHC genes and sequence diversity varies greatly among taxa, believed due to evolutionary history and differential...

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PMID: 37355591
DOI: 10.1186/s12862-023-02135-9
PMCID: PMC10290333

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