Article
Pretreatment viral quasispecies characteristics and evolutionary phases correlate with HBsAg seroconversion in peginterferon-alfa-2a-treated children with HBeAg-positive chronic hepatitis B.
Antiviral research - 1 Dec 2025
Yang Juncheng, Yang Guifeng, He Haitang, Liu Hai, Fu Qunfang, Wu Xiaoting, Meng Ran, Li Zhuoyue, Zhao Qian, Luo Kangxian, Liu Zhihua
Abstract excerpt
BACKGROUND & AIMS: To evaluate baseline HBV quasispecies (QS) characteristics as a predictor of HBsAg seroconversion in peginterferon-alfa-2a-treated HBeAg-positive pediatric chronic hepatitis B (CHB). METHODS: 25 patients achieved HBsAg seroconversion (SS group) and another 25 did not (SN group) were enrolled, matched for baseline profiles. Full-length HBV genomes were obtained from pretreatment serum via clone...
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