Article

Multi-level Latent Variable Models for Coheritability Analysis in Electronic Health Records

2025-11-06

Abstract excerpt

Electronic health records (EHRs) linked with familial relationship data offer a unique opportunity to investigate the genetic architecture of complex phenotypes at scale. However, existing heritability and coheritability estimation methods often fail to account for the intricacies of familial correlation structures, heterogeneity across phenotype types, and computational scalability. We propose a robust and flexib...

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Literature Corpus work: 5d6f9e57-05fb-5762-b7e1-455ad5ee2fc9
DOI: 10.1101/2025.11.05.25339602

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