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Article

Association of Metabolic Genotype Composite CYP3A53 and CYP3A41B to Tacrolimus Pharmacokinetics in Stable Black and White Kidney Transplant Recipients.

Clinical and translational science - 1 Oct 2025

Brazeau Daniel, Attwood Kristopher, Cooper Louse M, Gray Vanessa, Chang Shirley, Chen Shirley, Murray Brian M, Tornatore Kathleen M

Abstract excerpt

Interpatient variability in tacrolimus pharmacokinetics is due in part to variation in metabolism by cytochrome P-450 3A5 and 3A4 and membrane transport by P-glycoprotein. We evaluated the combined role CYP3A5*3 and CYP3A4*1B genotypes have on tacrolimus pharmacokinetics in 65 stable Black and White kidney transplant recipients receiving maintenance immunosuppression of tacrolimus and mycophenolic acid....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41081554
DOI: 10.1111/cts.70370
PMCID: PMC12516915

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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