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Article

Composite CYP3A phenotypes influence tacrolimus dose-adjusted concentration in lung transplant recipients.

Pharmacogenetics and genomics - 1 Jul 2022

Liu Michelle, Shaver Ciara M, Birdwell Kelly A, Heeney Stephanie A, Shaffer Christian M, Van Driest Sara L

Abstract excerpt

OBJECTIVES: Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A4/5 isoenzymes (encoded by CYP3A4 and CYP3A5). Guidelines for adjusting tacrolimus based on CYP3A5 test results are published; however, CYP3A4 variants also contribute to the variability in tacrolimus pharmacokinetics. The effects of composite phenotypes incorporating CYP3A5 and CYP3A4 increased...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 35389944
DOI: 10.1097/FPC.0000000000000472
PMCID: PMC9177686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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