Tacrolimus Elimination in Four Patients With a CYP 3A5*3/*3 CYP 3A4*22/*22 Genotype Combination

Abstract excerpt

Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme production. CYP3A4*22 is a variant that reduces production of functional CYP3A4 protein. Caucasians...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV/AIDS drug development and treatment
• Share to Pharmacological Effects and Toxicity Studies
• Share to Renal Transplantation Outcomes and Treatments