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Article

Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations.

Cell genomics - 10 Dec 2025

Pallares Luisa F, Melo Diogo, Wolf Scott, Cofer Evan M, Abhyankar Varada, Peng Julie, Ayroles Julien F

Abstract excerpt

Most genetic polymorphisms associated with complex traits are found in non-coding regions of the genome. Characterizing their effect presents a formidable challenge, and expression quantitative trait locus (eQTLs) mapping has been a key approach to do so. As comprehensive eQTL maps are available only for a few species, here we developed the Drosophila outbred synthetic population (Dros-OSP) and used it to...

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Topics

Animals
Quantitative Trait Loci
Drosophila melanogaster
Transcriptome
Chromosome Mapping
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Variation

Genome, Insect

Transcription, Genetic

Male

Source

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Identifiers

PMID: 41075790
DOI: 10.1016/j.xgen.2025.101033
PMCID: PMC12802594

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