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Article

The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.

Nature communications - 10 Oct 2025

Arruda Ana Luiza, Bocher Ozvan, Taylor Henry J, Cammann Davis, Yoshiji Satoshi, Yin Xianyong, Zhao Chi, Chen Jingchun, Wood Alexis C, Suzuki Ken, Mercader Josep M, Spracklen Cassandra N, Meigs James B, Vujkovic Marijana, Smith George Davey, Rotter Jerome I, Voight Benjamin F, Morris Andrew P, Zeggini Eleftheria

Abstract excerpt

Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization analysis using genome-wide association studies across multiple genetic ancestries. Additionally, leveraging eight mechanistic clusters of type 2 diabetes genetic...

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Identifiers

PMID: 41073432
DOI: 10.1038/s41467-025-64927-5
PMCID: PMC12514310

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