ASPL couples the assembly of stress granules with their VCP-mediated disassembly.

doi:10.1126/sciadv.ady3735

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Article

ASPL couples the assembly of stress granules with their VCP-mediated disassembly.

Science advances - 10 Oct 2025

Pareek Gautam, Li Dongfang, Wang Bo, Wu Jinjun, Freibaum Brian D, Basalla Joseph L, Mahendran Tharun Selvam, Singh Anurag, Nourse Amanda, Quan Honghu, Kalathur Ravi, Rana Mitra S, Maxwell Brian, Wang Yong-Dong, Messing James, Ni Yonghui, Pounds Stanley, Dharmat Rachayata, Lu Jingjun, Li-Harms Xiujie, Carisey Alexandre F, Pruett-Miller Shondra M, Taylor J Paul, Banerjee Priya, Kim Hong Joo, Kundu Mondira

Abstract excerpt

Stress granules (SGs) are dynamic RNA-protein assemblies that form in response to cellular stress and must be efficiently disassembled to restore normal cell function. Valosin-containing protein (VCP), an enzyme implicated in neurodegenerative diseases, is essential for SG disassembly, but whether and how this process is coordinated with SG assembly remains unclear. Here, we identify the VCP cofactor, Alveolar...

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Identifiers

PMID: 41061052
DOI: 10.1126/sciadv.ady3735
PMCID: PMC12506973

Genes

VCP
ULK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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