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Article

MmpL12 transports lipooligosaccharides and impacts virulence in Mycobacterium marinum.

Microbiology (Reading, England) - 1 Oct 2025

Bailo Rebeca, Kumar C M Santosh, Singh Albel, Lund Peter A, Bavro Vassiliy N, Bhatt Apoorva

Abstract excerpt

Lipooligosaccharides (LOSs) are polar glycolipids found in the cell envelope of many pathogenic mycobacteria. Here, we show that LOS transport in Mycobacterium marinum requires mmpL12, a member of the resistance-nodulation-division family of membrane proteins. Deletion of mmpL12 resulted in a rough colony morphology and increased hydrophobicity. The △mmpL12 mutant accumulated three of the biosynthesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41060696
DOI: 10.1099/mic.0.001618
PMCID: PMC12507525

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