Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder.

doi:10.1038/s41598-018-20194-7

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Article

Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder.

Scientific reports - 30 Jan 2018

Pagerols Mireia, Richarte Vanesa, Sánchez-Mora Cristina, Rovira Paula, Soler Artigas María, Garcia-Martínez Iris, Calvo-Sánchez Eva, Corrales Montse, da Silva Bruna Santos, Mota Nina Roth, Victor Marcelo Moraes, Rohde Luis Augusto, Grevet Eugenio Horacio, Bau Claiton Henrique Dotto, Cormand Bru, Casas Miguel, Ramos-Quiroga Josep Antoni, Ribasés Marta

Abstract excerpt

Methylphenidate (MPH) is the most frequently used pharmacological treatment in children with attention-deficit/hyperactivity disorder (ADHD). However, a considerable interindividual variability exists in clinical outcome. Thus, we performed a genome-wide association study of MPH efficacy in 173 ADHD paediatric patients. Although no variant reached genome-wide significance, the set of genes containing...

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PMID: 29382897
DOI: 10.1038/s41598-018-20194-7
PMCID: PMC5789875

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