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Article

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD.

Molecular psychiatry - 1 Sept 2018

Myer N M, Boland J R, Faraone S V

Abstract excerpt

Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components...

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Topics

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Share to Attention Deficit Disorder with Hyperactivity
Share to Biomarkers, Pharmacological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Dopamine Plasma Membrane Transport Proteins

Share to Methylphenidate

Share to Norepinephrine Plasma Membrane Transport Proteins

Share to Receptors, Adrenergic, alpha-2

Share to Receptors, Dopamine D4

Source

Open in PubMed Open full text

Identifiers

PMID: 29230023
DOI: 10.1038/mp.2017.234
PMCID: PMC7039663

Genes

DRD4
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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