Co-detection of mutations and methylations in cerebrospinal fluid ctdna for minimally-invasive diagnosis of brainstem glioma.

doi:10.1186/s13046-025-03455-y

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Article

Co-detection of mutations and methylations in cerebrospinal fluid ctdna for minimally-invasive diagnosis of brainstem glioma.

Journal of experimental & clinical cancer research : CR - 7 Oct 2025

Li Tian, Wang Huan, Wang Yujin, Mai Yiying, Wang Pei, Zhang Mingxin, Jiang Zhuang, Xie Luyang, Zhou Hang, Wang Yi, Li Xiaoou, Xiao Dan, Geng Jingyao, Wu Wenhao, Zhang Peng, Wang Liang, Wu Zhen, Zhang Junting, Cao Dandan, Pan Changchun, Zhang Liwei

Abstract excerpt

BACKGROUND: Genetic and epigenetic profiles are critical in managing brainstem gliomas (BSG), whose heterogeneity is far beyond the realm of the Diffuse midline glioma, H3K27 altered. Cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA)-based liquid biopsy provides minimally-invasive strategies to acquire molecular information for brain tumors, whereas there is a deficiency in techniques for co-detection of...

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Topics

Humans
Glioma
Brain Stem Neoplasms
Circulating Tumor DNA
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Mutation

DNA Methylation

Middle Aged

Adult

Prognosis

Biomarkers, Tumor

Aged

Young Adult

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 41057970
DOI: 10.1186/s13046-025-03455-y
PMCID: PMC12502398

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