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A serum-based DNA methylation assay provides accurate detection of glioma

3 Feb 2021

Abstract excerpt

BACKGROUND: The detection of somatic mutations in cell-free DNA (cfDNA) from liquid biopsy has emerged as a noninvasive tool to monitor the follow-up of cancer patients. However, the significance of cfDNA clinical utility remains uncertain in patients with brain tumors, primarily because of the limited sensitivity cfDNA has to detect real tumor-specific somatic mutations. This unresolved challenge has prevented...

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PMID: 33560371
DOI: 10.1093/neuonc/noab023

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