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Article

Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma.

Science advances - 1 Oct 2020

Li Jia, Zhao Sibo, Lee Minjung, Yin Yue, Li Jin, Zhou Yubin, Ballester Leomar Y, Esquenazi Yoshua, Dashwood Roderick H, Davies Peter J A, Parsons D Williams, Li Xiao-Nan, Huang Yun, Sun Deqiang

Abstract excerpt

Medulloblastoma (MB), the most common form of pediatric brain malignancy, has a low frequency of oncogenic mutations but pronouncedly abnormal DNA methylation changes. Epigenetic analysis of circulating cell-free tumor DNA (ctDNA) by liquid biopsy offers an approach for real-time monitoring of tumor status without tumor dissection. In this study, we identified 6598 differentially methylated CpGs in both MB tumors...

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Open in PubMed Open full text

Identifiers

PMID: 33067228
DOI: 10.1126/sciadv.abb5427
PMCID: PMC7567591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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