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Article

The Impact of CYP3A4, COMT V158M, and OPRM A118G Gene Polymorphisms on the Effectiveness of Sufentanil in Labor Analgesia.

Journal of visualized experiments : JoVE - 16 Sept 2025

Huang Huiqiong, Zhang Yunhong, Jia Junxiang, Zhu Zhuanghui

Abstract excerpt

Genetic polymorphisms in CYP3A4, COMT V158M, and OPRM A118G may influence analgesic response, hemodynamic regulation, and postpartum recovery, while parity is thought to affect labor outcomes and adverse events. This study investigated how these genotypes and parity impact maternal and neonatal outcomes, labor duration, pain control, and postpartum complications in 380 pregnant women stratified by genotype. Data...

Read the complete abstract on PubMed

Topics

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Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Pregnancy

Share to Receptors, Opioid, mu

Share to Young Adult

Source

Identifiers

PMID: 41052036
DOI: 10.3791/69160

Genes

CYP3A4
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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