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CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection

28 Feb 2023

Abstract excerpt

Globally, most cases of gastroenteritis are caused by pandemic GII.4 human norovirus (HuNoV) strains with no approved therapies or vaccines available. The cellular pathways that these strains exploit for cell entry and internalization are unknown. Here, using nontransformed human jejunal enteroids (HIEs) that recapitulate the physiology of the gastrointestinal tract, we show that infectious GII.4 virions and...

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PMID: 36854760
DOI: 10.1038/s41467-023-36398-z

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