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Article

Discrepancies in isoniazid susceptibility profiles: Bactec MGIT 960-resistant but GenoType MTBDRplus-susceptible Mycobacterium tuberculosis strains in Hunan, China.

Microbiology spectrum - 4 Nov 2025

Chen Zhenhua, Hu Peilei, Guo Jingwei, Wang Jue, Liu Binbin, Tan Yunhong

Abstract excerpt

Discordant drug susceptibility testing (DST) results between the Bactec MGIT 960 system (MGIT) and the GenoType MTBDRplus assay (MTBDRplus) for isoniazid (INH) complicate clinical decision-making. In this study, we performed minimum inhibitory concentration (MIC) assays and whole-genome sequencing (WGS) on 53 Mycobacterium tuberculosis strains identified as INH-resistant by MGIT but INH-susceptible by MTBDRplus....

Read the complete abstract on PubMed

Topics

Isoniazid
Mycobacterium tuberculosis
Antitubercular Agents
Microbial Sensitivity Tests
Humans
China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Whole Genome Sequencing

Genotype

Bacterial Proteins

Drug Resistance, Bacterial

Mutation

Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 41031815
DOI: 10.1128/spectrum.01101-25
PMCID: PMC12584712

Genes

DST

Provenance

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