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Article

Chimeric reference panels for genomic imputation.

Genetics - 7 Jan 2026

Zhou Meikun, James Maddie E, Engelstädter Jan, Ortiz-Barrientos Daniel

Abstract excerpt

Despite transformative advances in genomic technologies, missing data remain a fundamental constraint that limits the full potential of genomic research across biological systems. Genotype imputation offers a remedy by inferring unobserved genotypes from observed data. However, conventional imputation methods typically rely on external reference panels constructed from complete genome sequences of hundreds of...

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PMID: 41030062
DOI: 10.1093/genetics/iyaf212
PMCID: PMC12774824

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