Article

SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron

2021-12-28

Abstract excerpt

<h4>Summary</h4> The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that contribute to escape from the neutralizing antibody responses, and reducing vaccine protection from infection. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b7aa48f-f4df-5dc5-8082-2136e87f17da
DOI: 10.1101/2021.12.26.21268380

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against OmicronDOI 10.1101/2021.12.26.21268380Read

T cell responses to SARS-CoV-2 spike cross-recognize OmicronSemantic proximity Read

T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individualsSemantic proximity Read

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanismSemantic proximity Read

Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutations.Semantic proximity Read

Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variantSemantic proximity Read

SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron.Semantic proximity Read

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySemantic proximity Read

Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals.Semantic proximity Read

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adultsSemantic proximity Read

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus VaccinesSemantic proximity Read

Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike ProteinSemantic proximity Read

COVID‐19: Omicron – the latest, the least virulent, but probably not the last variant of concern of SARS‐CoV‐2Semantic proximity Read