Article

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron

2022-10-14

Abstract excerpt

The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date 1–7 . The Omicron spike (S) protein, with an unusually large number of mutations, is considered the major driver of these phenotypes 3,8 . We generated chimeric recombinant SARS-CoV-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1c99c77-19cf-59ee-82bd-7d4d9ac0f1a6
DOI: 10.1101/2022.10.13.512134

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 OmicronDOI 10.1101/2022.10.13.512134Read

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.Semantic proximity Read

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySemantic proximity Read

Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutations.Semantic proximity Read

Emerging SARS-CoV-2 variants: Why, how, and what's next?Semantic proximity Read

Functional and Structural Basis of Omicron BA.3.2.1 SpikeSemantic proximity Read

A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity.Semantic proximity Read

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanismSemantic proximity Read

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spikeSemantic proximity Read

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2.Semantic proximity Read

"Is Omicron mild"? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies.Semantic proximity Read

Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune responseSemantic proximity Read

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein.Semantic proximity Read