Article
Non-cell-autonomous tumor promotion in DICER1 cancer predisposition.
Developmental cell - 14 Jan 2026
Larsen Randolph K, Hanna Jason A, Jin Hongjian, Reed Kristin B, Kimbrough Darden W, Vuong Kyna, Hwang Jongchan, Adkins Grace E, Hopkins Jack D, Stevens Bradley T, Evans Myron K, Langdon Casey G, Drummond Catherine J, Garcia Matthew R, Wiggins Kristin B, Iverson Amy R, Finkelstein David, Schreiner Patrick A, Rosch Jason W, Rehg Jerold E, Schultz Kris Ann P, Hatley Mark E
Abstract excerpt
DICER1-related tumors are characterized by germline loss-of-function mutations in one DICER1 allele (DICER1+/-) and a somatic "second hit" mutation in the remaining DICER1 allele. Whether the germline DICER1+/- mutation participates in tumorigenesis is unknown. We show that germline heterozygous loss of Dicer1 promotes tumor formation via aberrant neutrophil function in spontaneous and allograft mouse models of...
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