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Article

Spatial single cell transcriptomic analysis informs tumor developmental hierarchy of DICER1 syndrome related sarcoma.

Nature communications - 30 Mar 2026

Kommoss Felix K F, Zhang Joyce Yu Han, Lynch Branden J, Chen Shary Yuting, Senz Janine, Moscovitz Yana, Hill Lesley A, Ma Ding, Scott R Wilder, Bush Jonathan, Chen Kenneth S, Roth Andrew, von Deimling Andreas, Foulkes William D, Morin Gregg B, Underhill T Michael, Wang Yemin, Huntsman David G

Abstract excerpt

DICER1-related tumor predisposition (DRTP), also known as DICER1 syndrome, encompasses a spectrum of malignancies mainly in children and young adults. Most are sarcomas, exhibiting histological and molecular similarities regardless of their anatomical origins, and only express the RNase IIIb domain-defective DICER1. To uncover their cellular origin and developmental hierarchy, we establish a lineage-traceable...

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Identifiers

PMID: 41912509
DOI: 10.1038/s41467-026-70971-6
PMCID: PMC13199431

Genes

DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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