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Article

Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing.

The Journal of antimicrobial chemotherapy - 1 Jun 2014

Dolton Michael J, Mikus Gerd, Weiss Johanna, Ray John E, McLachlan Andrew J

Abstract excerpt

OBJECTIVES: Voriconazole exhibits highly variable, non-linear pharmacokinetics and is associated with a narrow therapeutic range. This study aimed to investigate the population pharmacokinetics of voriconazole in adults, including the effect of CYP2C19 genotype and drug-drug interactions. METHODS: Non-linear mixed effects modelling (NONMEM) was undertaken of six voriconazole studies in healthy volunteers and...

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PMID: 24554646
DOI: 10.1093/jac/dku031

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