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Article

CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole.

Journal of clinical pharmacology - 1 Feb 2009

Weiss Johanna, Ten Hoevel Magdalena Maria, Burhenne Jürgen, Walter-Sack Ingeborg, Hoffmann Michael Marcus, Rengelshausen Jens, Haefeli Walter E, Mikus Gerd

Abstract excerpt

In vitro data on the metabolism of the antifungal voriconazole suggest that its pharmacokinetics might be influenced by the activity of CYP2C19, CYP2C9, and CYP3A. To elucidate the genetic influence of polymorphic enzymes on voriconazole metabolism, the authors pooled the pharmacokinetic data from 2 interaction studies in which 35 participants were enrolled according to their CYP2C19 genotype to receive a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Source

Identifiers

PMID: 19033450
DOI: 10.1177/0091270008327537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole.PMID 19033450Read ↗

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