Real-World Molecular Testing in European Early-Onset Colorectal Cancer.

doi:10.1002/ueg2.70112

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Article

Real-World Molecular Testing in European Early-Onset Colorectal Cancer.

United European gastroenterology journal - 1 Dec 2025

Edwards Penelope V, Ali Eloussta Kussai Giuma, Latchford Andrew, Faiz Omar, Thomas Huw, Liccardo Filomena, Pawa Nikhil, Hüneburg Robert, Nattermann Jacob, George Andrew, Balaguer Francesc, Martí Marc, Spinelli Antonino, Foppa Caterina, de Miranda Noel F F C, López Irene, Hurtado Elena, Jiménez Fernando, Jiménez-Toscano Marta, Álvaro Edurne, Sanz Gonzalo, Ballestero Araceli, Rueda José A, Viyuela Cristina, Brandáriz Lorena, Vidal-Tocino Rosario, García-Olmo Damián, Pastor Carlos, González-Sarmiento Rogelio, Holowatyj Andreana N, McVeigh Terri, Perea José, Monahan Kevin J

Abstract excerpt

PURPOSE: The global incidence and mortality of early-age onset colorectal cancer (EOCRC, or CRC diagnosed under 50 years) has increased in recent decades. High-risk surveillance and personalised oncological treatment may improve patients' outcomes. This study aims to characterise real-world somatic and germline molecular profiles in European EOCRC patients. PATIENTS AND METHODS: Consecutive patients across the...

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Identifiers

PMID: 41014296
DOI: 10.1002/ueg2.70112
PMCID: PMC12704576

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