Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer.

doi:10.1158/2767-9764.CRC-24-0368

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Article

Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer.

Cancer research communications - 1 Dec 2024

Francis Rachel A, Tavtigian Sean, Horton Carolyn, Holowatyj Andreana N

Abstract excerpt

ABSTRACT: The increasing burden of colorectal cancer among adults younger than age 50 years (early-onset colorectal cancer) and new National Comprehensive Cancer Network guidelines recommending universal genetic testing in early-onset colorectal cancer emphasize the need for accurate and timely variant classification in clinical care. In this study, we investigated germline variant of uncertain significance (VUS)...

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Identifiers

PMID: 39656055
DOI: 10.1158/2767-9764.CRC-24-0368
PMCID: PMC11824576

Genes

MSH2
PMS2

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