Article

Next generation sequencing identifies a pattern of novel germline variants in early-onset colorectal cancer

2024-12-12

Abstract excerpt

Early-onset colorectal cancer (EOCRC) incidence is increasing rapidly worldwide. However, the majority of EOCRCs are not substantiated by germline variants in the main colorectal cancer (CRC) predisposition genes (the “DIGE” panel). To investigate a potential genetic transmission of EOCRC (dominant, recessive and oligogenic hypotheses) and thus identify potentially novel EOCRC-specific predisposition genes, we con...

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Literature Corpus work: caa20e76-432d-5e6a-9246-93fdf5055d40
DOI: 10.1101/2024.12.09.627474

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